Version 2.77

Descriptions

Xanthines are a group of alkaloids that are commonly used for their effects as mild stimulants and as bronchodilators, notably in treating the symptoms of asthma. Their effects, however, are widespread and their therapeutic range is narrow and so they are not the drug of choice in asthma treatment. Methylated xanthine derivatives include caffeine, theophylline, and theobromine (found mainly in chocolate). These drugs inhibit phosphodiesterase and antagonise adenosine. The core compound, xanthine, is a product on the pathway of purine degradation and is converted to uric acid by the action of the xanthine oxidase enzyme. Some people lack sufficient xanthine oxidase, and thus xanthine cannot be converted to uric acid. This rare genetic disorder is called xanthinuria. Xanthines are purine derivatives and found very rarely in constituents of nucleic acids. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Xanthine (Wikipedia)

A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed) Source: National Library of Medicine, MeSH 2006

Xanthine is a product on the pathway of purine degradation and is converted to uric acid by the action of the xanthine oxidase (xanthine dehydrogenase) enzyme. Some people lack sufficient xanthine oxidase, and thus xanthine cannot be converted to uric acid. This rare genetic disorder is called xanthinuria results from excessive excretion of xanthine into the urine. This disorder can result in urolithiasis and sometimes myopathy from xanthine deposition. Elevated xanthine can also result from allopurinol treatment. Xanthine is also the core chemical component of a group of alkaloids that are commonly used for their effects as mild stimulants and as bronchodilators, notably in treating the symptoms of asthma. Their effects, however, are widespread and their therapeutic range is narrow and so they are not the drug of choice in asthma treatment. Methylated xanthine derivatives include caffeine, theophylline, and theobromine (found mainly in chocolate). These drugs inhibit phosphodiesterase and antagonise adenoine. Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Xanthine
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
Xanthine

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP15953-0
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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 黄嘌呤
Synonyms: 2,6-二羟基嘌呤;花黄素;黄尿环;黄质
fr-CA French (Canada) Xanthine
et-EE Estonian (Estonia) Ksantiin
es-ES Spanish (Spain) Xantina
it-IT Italian (Italy) Xantina
tr-TR Turkish (Turkey) Ksantin
ru-RU Russian (Russian Federation) Ксантин
nl-NL Dutch (Netherlands) xanthine
fr-BE French (Belgium) Xanthine