Version 2.77


High-dose methotrexate (MTX) is an antimetabolite drug used in treatment of cancer, and low-dose methotrexate (MTX) is used as a disease modifying antirheumatic drug (DMARD) for long-term treatment of rheumatoid arthritis (RA), psoriasis, and other autoimmune diseases. Methotrexate is a first-line drug in RA treatment. One challenge in the use of the drug is that about 30% of patients do not respond to treatment or experience adverse effects, such as gastrointestinal symptoms, malaise, and psychological complaints. PMID: 20665136 Source: Regenstrief LOINC, PMID: 20665136

An anti-neoplastic anti-metabolite with immunosuppressant properties. It inhibits tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, an essential component of DNA, necessary for synthesis of thymidylate. Source: National Library of Medicine, MeSH 2006

Basic Part Properties

Part Display Name
Part Type
Component (Describes the core component or analyte measured)
Created On
Construct for LOINC Short Name

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup$lookup?system=
ConceptMap translate$translate?system=

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 氨甲喋呤
Synonyms: C20H22N8O5;甲氨喋呤;氨甲基叶酸;氨甲蝶呤;甲基蝶啶胺;甲基蝶啶胺(化学不孕剂)
fr-CA French (Canada) Méthotrexate
et-EE Estonian (Estonia) Metotreksaat
es-ES Spanish (Spain) Metotrexato
it-IT Italian (Italy) Metotrexato
tr-TR Turkish (Turkey) Metotreksat
ru-RU Russian (Russian Federation) Метотрексат
nl-NL Dutch (Netherlands) methotrexaat
fr-BE French (Belgium) Méthotrexate