Version 2.74


Thioridazine (Mellaril, Melleril, Sonapax, Thioril) is a piperidine typical antipsychotic drug of the phenothiazine drug class and was previously widely used in the treatment of schizophrenia and psychosis. Due to concerns about cardiotoxicity and retinopathy at high doses it has been withdrawn in many countries (including the UK and Australia) and in other countries it is not commonly prescribed, reserved for patients who have failed to respond to, or have contraindications for, more widely used antipsychotics. It has been tried with some success as a treatment for various psychiatric symptoms seen in patients with dementia. Thioridazine is known to kill intracellular extensively drug-resistant (XDR) Mycobacterium tuberculosis and both inhibit MRSA directly but also increase the susceptibility of MRSA to β-lactam antibiotics at clinical concentrations. It also appears to increase the efficacy of standard antimicrobial agents (even ones to which the strain in question is resistant) in treating XDR-tuberculosis (XDR-TB) via inhibiting bacterial efflux pumps.(Wikipedia) Source: Regenstrief LOINC, Thioridazine

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Language Variants

Tag Language Translation
zh-CN Chinese (China) 甲硫哒嗪
Synonyms: 10-β-甲基哌啶乙基-2-甲硫基吩噻嗪;C21H26N2S2;甲硫基吩噻嗪;硫利达嗪;硫组氨酸;硫醚嗪
fr-CA French (Canada) Thioridazine
et-EE Estonian (Estonia) Tioridasiin
es-ES Spanish (Spain) Tioridazina
it-IT Italian (Italy) Tioridazina
tr-TR Turkish (Turkey) Tiyoridazin
ru-RU Russian (Russian Federation) Тиоридазин
nl-NL Dutch (Netherlands) thioridazine
fr-BE French (Belgium) Thioridazine