LP16359-9
Complement C3
Active
Descriptions
Soluble C3-convertase, also known as iC3Bb, catalyzes the proteolytic cleavage of complement component C3 into C3a and C3b during the alternate complement pathway. C3b binds to microbial pathgens leading to the production of surface-bound C3 convertase and then to more C3b. Also known as C3bBb, this convertase is similar to soluble C3-convertase except that it is membrane bound. Bound C3b facilitates opsonization of pathogens by macrophages. Complement receptor 1 (CR1) on macrophages mediates the destruction of C3b-covered microbes. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Complement C3 (Wikipedia)
A glycoprotein central in both the classical and alternate pathways of complement systems. C3 can be cleaved into C3a and C3b fragments either spontaneously at low level, or at a higher rate by C3 convertase. C3a is an anaphylotoxin and a mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase. Source: National Library of Medicine, MeSH 2006
The complement system is a key part of the immune system and inflammatory response. The system has three pathways: 1) the classic pathway, 2) the alternative pathway, and 3) the lectin activation pathway. Complement C3 is involved in the activation of both the classical and alternate complement pathways. It is the most concentrated of the complement members and is composed of 5 subunits: C3a, C3b, C3c, C3d and C3 d. Decreased levels of C3 is associated with disease inactivation in systemic lupus erythematosus (SLE) and may also be associated with acute glomerulonephritis, immune complex disease, septic shock, and end-stage liver disease. PMID: 6433145 PMID: 3295544 Complement tests measure either the quantity or the activity (function) of complement proteins. In some cases, complement proteins are present but not functional, in which case a functional assay is used to detect the deficiency. Source: Regenstrief Institute
Basic Part Properties
- Part Display Name
- Complement C3
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- C3
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 补体 C3 |
| fr-CA | French (Canada) | Complément C3 |
| et-EE | Estonian (Estonia) | Komplemendi komponent C3 |
| es-ES | Spanish (Spain) | Complemento C3 |
| it-IT | Italian (Italy) | Complemento C3 |
| el-GR | Greek (Greece) | C3 παράγοντας συμπληρώματος |
| tr-TR | Turkish (Turkey) | Kompleman C3 |
| ru-RU | Russian (Russian Federation) | Комплемент С3 |
| nl-NL | Dutch (Netherlands) | complement C3 |
| fr-BE | French (Belgium) | Complément C3 |
LOINC Copyright
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