LP16472-0
Interleukin 4
Active
Descriptions
Interleukin-4, abbreviated IL-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4. The cell that initially produces IL-4, thus inducing Th0 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell.
It has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. Overproduction of IL-4 is associated with allergies.
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Source: Wikipedia, Wikipedia
The Interleukins belong to the family termed cytokines. They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells. Interleukin 4 is a 20,000 molecular weight glycoprotein originally called T Cell Growth Factor along with Interleukin 2. It is released primarily by activated T Cells and mast cells. Its primary target cells are T and B cells, macrophage/monocytes, and mast cells. Interleukin 4 activates B cell differentiation and immunoglobulins prior to action of Interleukin 6. It is also a co-stimulator along with anti-immunoglobulin antibodies of B cell proliferation. Interleukin 4 is bound to receptors located on activated T cells, resting and activated B cells, macrophages, and mast cells. Source: Inter Science Institute, Inter Science Institute
Basic Part Properties
- Part Display Name
- Interleukin 4
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Il4
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 白细胞介素 4 Synonyms: B 细胞刺激因子-1; |
| fr-CA | French (Canada) | Interleukine 4 |
| et-EE | Estonian (Estonia) | Interleukiin 4 |
| es-ES | Spanish (Spain) | Interleukina 4 |
| it-IT | Italian (Italy) | Interleuchina 4 |
| tr-TR | Turkish (Turkey) | İnterlökin 4 |
| ru-RU | Russian (Russian Federation) | Интерлейкин 4 |
| nl-NL | Dutch (Netherlands) | interleukine 4 |
| fr-BE | French (Belgium) | Interleukine 4 Synonyms: Il4 |
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