LP16473-8
Interleukin 5
Active
Descriptions
Interleukin 5 or IL-5 is an interleukin produced by T helper-2 cells and mast cells. Its functions are to stimulate B cell growth and increase immunoglobulin secretion. It is also a key mediator in eosinophil activation. IL-5 is a 115 amino acid (in man, 133 in the mouse) long TH2 cytokine which is part of the hematopoietic family.Interleukin-5 is also expressed by eosinophils and has been observed in the mast cells of asthmatic airways by immunohistochemistry. IL-5 expression is regulated by several transcription factors including GATA3. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia
The Interleukins belong to the family termed cytokines. They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells. Interleukin 5 is a 50,000-60,000 molecular weight glycoprotein originally called T Cell Replacing Factor. It is released primarily by activated T Cells. Its primary target cells are B cells and eosinophils. Interleukin 5 activates B cell differentiation. Its actions are similar to Interleukin 3. Interleukin 5 primes basophils for agonist-induced generation of Leukotriene C4. It is stimulated by Interleukin 2. Interleukin 5 stimulates growth and differentiation of eosinophil progenitor without influencing cells committed to neutrophils, basophils, or monocytes. It enhances responsiveness of eosinophils inducing polarization, shape change, chemotaxis, cytotoxity, oxygen radical release and prolongs survival. Source: Inter Science Institute, Inter Science Institute
Basic Part Properties
- Part Display Name
- Interleukin 5
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Il5
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 白细胞介素 5 Synonyms: B 细胞生长因子-II; |
| fr-CA | French (Canada) | Interleukine 5 |
| et-EE | Estonian (Estonia) | Interleukiin 5 |
| es-ES | Spanish (Spain) | Interleuquina 5 |
| it-IT | Italian (Italy) | Interleuchina 5 |
| tr-TR | Turkish (Turkey) | İnterlökin 5 |
| ru-RU | Russian (Russian Federation) | Интерлейкин 5 |
| nl-NL | Dutch (Netherlands) | interleukine 5 |
| fr-BE | French (Belgium) | Interleukine 5 Synonyms: Il5 |
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