LP16475-3
Interleukin 7
Active
Descriptions
Interleukin 7 (IL7) is a protein[1] that is encoded by the IL7 gene in humans.
IL-7 a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, neurons and endothelial cells, but is not produced by lymphocytes. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells (as opposed to myeloid progenitor cells where differentiation is stimulated by IL-3). It also stimulates proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells). It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis.
IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.
IL-7 receptor knockout mice exhibit thymic atrophy, arrest of T-cell development at the double positive stage, and severe lymphopenia. Administration of IL-7 to mice results in an increase in thymic migrants, increases in B and T cells, and increased recovery of T cells after cyclophosphamide administration or after bone marrow transplantation.
Il-7 promotes hematological malignacies (acute lymphoblastic leukemia, T cell lymphoma).
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Source: Wikipedia, Wikipedia
The Interleukins belong to the family termed cytokines. They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells. Interleukin 7 is a 25,000 molecular weight glycoprotein produced primarily in bone marrow stromal cells. Its primary target cells are B cells. Interleukin 7 supports long term culture of B cells. Interleukin 7 plays an important role in maintenance of a population of pre B lymphocytes although it does not stimulate differention of pre B cells to B cells. Interleukin 7 also activates myeloid cell proliferation and differentiation. Source: Inter Science Institute, Inter Science Institute
Basic Part Properties
- Part Display Name
- Interleukin 7
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Il7
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 白细胞介素 7 Synonyms: I L7; |
| fr-CA | French (Canada) | Interleukine 7 |
| es-ES | Spanish (Spain) | Interleuquina 7 |
| it-IT | Italian (Italy) | Interleuchina 7 |
| tr-TR | Turkish (Turkey) | İnterlökin 7 |
| ru-RU | Russian (Russian Federation) | Интерлейкин 7 |
| nl-NL | Dutch (Netherlands) | interleukine 7 |
| fr-BE | French (Belgium) | Interleukine 7 Synonyms: Il7 |
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