LP16482-9
Plasminogen
Active
Descriptions
Plasmin, an enzyme that degrades many blood plasma proteins (most notably fibrin clots) is released as a zymogen called plasminogen (PLG) from the liver into the systemic circulation. Two major glycoforms of plasminogen are present in humans - type I plasminogen contains two glycosylation moieties (N-linked to N289 and O-linked to T346), whereas type II plasmingen contains only a single O-linked sugar (O-linked to T346). Type II plasminogen is preferentially recruited to the cell surface over the type I glycoform. Conversely, type I plasminogen appears more readily recruited to blood clots.
Plasminogen deficiency in mice leads to defective liver repair, defective wound healing, reproductive abnormalities.
In human, a rare disorder called plasminogen deficiency type I (Online 'Mendelian Inheritance in Man' [OMIM: 217090] is caused by mutations of the PLG gene and is often manifested by ligneous conjunctivitis.
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Source: Wikipedia, Plasminogen (Wikipedia)
Precursor of fibrinolysin (plasmin). It is a single-chain beta-globulin of molecular weight 80-90,000 found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. It is used in wound debriding and has been investigated as a thrombolytic agent. Source: National Library of Medicine, MeSH 2006
Basic Part Properties
- Part Display Name
- Plasminogen
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- PLG
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 纤溶酶原 Synonyms: PLG; |
| fr-CA | French (Canada) | Plasminogène |
| et-EE | Estonian (Estonia) | Plasminogeen |
| es-ES | Spanish (Spain) | Plasminógeno |
| it-IT | Italian (Italy) | Plasminogeno |
| tr-TR | Turkish (Turkey) | Plazminojen |
| ru-RU | Russian (Russian Federation) | Плазминоген |
| nl-NL | Dutch (Netherlands) | plasminogeen |
| fr-BE | French (Belgium) | Plasminogène |
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