LP16482-9

Plasminogen

Active

Descriptions

Plasmin, an enzyme that degrades many blood plasma proteins (most notably fibrin clots) is released as a zymogen called plasminogen (PLG) from the liver into the systemic circulation. Two major glycoforms of plasminogen are present in humans - type I plasminogen contains two glycosylation moieties (N-linked to N289 and O-linked to T346), whereas type II plasmingen contains only a single O-linked sugar (O-linked to T346). Type II plasminogen is preferentially recruited to the cell surface over the type I glycoform. Conversely, type I plasminogen appears more readily recruited to blood clots.

Plasminogen deficiency in mice leads to defective liver repair, defective wound healing, reproductive abnormalities.

In human, a rare disorder called plasminogen deficiency type I (Online 'Mendelian Inheritance in Man' [OMIM: 217090] is caused by mutations of the PLG gene and is often manifested by ligneous conjunctivitis. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Plasminogen (Wikipedia)

Precursor of fibrinolysin (plasmin). It is a single-chain beta-globulin of molecular weight 80-90,000 found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. It is used in wound debriding and has been investigated as a thrombolytic agent. Source: National Library of Medicine, MeSH 2006

Basic Part Properties

Part Name

Plasminogen

Part Display Name

Plasminogen

Part Type

Component (Describes the core component or analyte measured)

Created On

2000-05-04

Construct for LOINC Short Name

PLG

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