Version 2.77


Histones are small nuclear proteins that together with dsDNA, represent a nucleosome, the structural unit of chromatin. Anti-histone antibodies are associated with various autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren's syndrome, systemic sclerosis, infectious diseases (including HIV), and some neurological disorders such as Alzheimer's disease and dementia. Nearly all patients with drug-induced SLE have anti-histone antibodies, but they are also present in patients with idiopathic forms of the disease. One study showed a correlation between SLE with positive anti-dsDNA, anti-nucleosome and anti-histone antibodies and renal disease, including proliferative glomerulonephritis. PMID: 24649358 Source: Regenstrief LOINC, PMID: 24649358

Basic Part Properties

Part Display Name
Part Type
Component (Describes the core component or analyte measured)
Created On
Construct for LOINC Short Name

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 组蛋白
Synonyms: 组朊
fr-CA French (Canada) Histone
et-EE Estonian (Estonia) Histoon
es-ES Spanish (Spain) Histona
it-IT Italian (Italy) Istone
tr-TR Turkish (Turkey) Histon
ru-RU Russian (Russian Federation) Гистон
nl-NL Dutch (Netherlands) histon
fr-BE French (Belgium) Histone