LP17229-3
Allo-tetrahydrocortisol
Active
Description
Allo-tetrahydrocortisol (5a-Tetrahydrocortisol) is a normal human metabolite. However its increased ratio (5alpha-Tetrahydrocortisol + Tetrahydrocortisol) over Tetrahydrocortisone in urine is the biochemical marker for the syndrome of apparent mineralocorticoid excess (AME). AME is a heritable form of hypertension due to an inborn error of cortisol metabolism and is characterized by hypokalemia and low renin levels despite subnormal or normal levels of aldosterone and other known mineralocorticoids. The syndrome is attributable to congenital deficiency of the enzyme 11 beta-hydroxydehydrogenase (11 beta-HSD), which converts cortisol to biologically inactive cortisone. This results in a prolonged half-life of Cortisol, which acts at the kidney level as a potent mineralocorticoid. [PMID :8732999]. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Allo-tetrahydrocortisol
Basic Part Properties
- Part Display Name
- Allo-tetrahydrocortisol
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Allo-THF
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 别-四氢皮质醇 Synonyms: Allo-THF; |
| fr-CA | French (Canada) | Allo-tétrahydrocortisol |
| et-EE | Estonian (Estonia) | Allo-tetrahüdrokortisool |
| es-ES | Spanish (Spain) | Alo-tetrahidrocortisol |
| it-IT | Italian (Italy) | Allo-tetraidrocortisolo |
| tr-TR | Turkish (Turkey) | Allo-tetrahidrokortizol |
| ru-RU | Russian (Russian Federation) | Алло-тетрагидрокортизол |
| nl-NL | Dutch (Netherlands) | allo-tetrahydrocortisol |
| fr-BE | French (Belgium) | Allo-tétrahydrocortisol |
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