LP17236-8
cloZAPine
Active
Descriptions
Clozapine (sold as Clozaril ®, Leponex ®, Fazaclo ®) was the first of the atypical antipsychotics to be developed. It was approved by the United States Food and Drug Administration (FDA) in 1989 and is the only FDA-approved medication indicated for treatment-resistant schizophrenia and for reducing the risk of suicidal behaviour in patients with schizophrenia. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Clozapine (Wikipedia)
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. Source: National Library of Medicine, MeSH 2006
Basic Part Properties
- Part Name
- cloZAPine
- Part Display Name
- cloZAPine
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- cloZAPine
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 氯氮平 Synonyms: 氯扎平 |
| fr-CA | French (Canada) | Clozapine |
| et-EE | Estonian (Estonia) | Klosapiin |
| es-ES | Spanish (Spain) | Clozapina |
| it-IT | Italian (Italy) | Clozapina |
| tr-TR | Turkish (Turkey) | Klozapine |
| ru-RU | Russian (Russian Federation) | Клозапин |
| nl-NL | Dutch (Netherlands) | clozapine |
| fr-BE | French (Belgium) | Clozapine |
| fr-FR | French (France) | Clozapine |
| el-GR | Greek (Greece) | Κλοζαπίνη Synonyms: Κλοζαπίνη |
LOINC Copyright
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