Version 2.77

Descriptions

Clozapine (sold as Clozaril ®, Leponex ®, Fazaclo ®) was the first of the atypical antipsychotics to be developed. It was approved by the United States Food and Drug Administration (FDA) in 1989 and is the only FDA-approved medication indicated for treatment-resistant schizophrenia and for reducing the risk of suicidal behaviour in patients with schizophrenia. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Clozapine (Wikipedia)

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. Source: National Library of Medicine, MeSH 2006

Basic Part Properties

Part Display Name
cloZAPine
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
cloZAPine

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 氯氮平
Synonyms: 氯扎平
fr-CA French (Canada) Clozapine
et-EE Estonian (Estonia) Klosapiin
es-ES Spanish (Spain) Clozapina
it-IT Italian (Italy) Clozapina
tr-TR Turkish (Turkey) Klozapine
ru-RU Russian (Russian Federation) Клозапин
nl-NL Dutch (Netherlands) clozapine
fr-BE French (Belgium) Clozapine