LP172561-5
Ceftolozane+Tazobactam
Active
Descriptions
Ceftolozane/tazobactam is a first-line IV therapy for the treatment of certain serious Gram-negative bacterial infections, including those caused by multi-drug resistant Pseudomonas aeruginosa. Source: Regenstrief LOINC
Ceftolozane is a cephalosporin with powerful activity against Gram-negative bacteria including Pseudomonas aeruginosa and Enterobacteriaceae.http://aac.asm.org/content/57/4/1577.full Tazobactam is a beta lactamase inhibitor and penicillin derivative that is effective against beta-lactamase-producing bacteria.[PubChem: 123630] Ceftolozane blocks penicillin binding proteins which disrupts bacterial cell-wall synthesis that leads to bacterial cell death. When tazobactam is added to ceftolozane, there is a broader spectrum of antimicrobial activity against resistant strains including extended spectrum beta-lactamases (ESBLs).Tazobactam prevents class A beta-lactamases and some class C beta-lactamases from hydrolyzing ceftolozane. Together, ceftolozane+tazobactam are an effective treatment for complicated urinary tract infections, complicated intra-abdominal infections, hospital-acquired bacterial pneumonia, and ventilator-associated bacterial pneumonia. PMID: 25516692 Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- Ceftolozane+Tazobactam
- Part Display Name
- Ceftolozane+Tazobactam
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2013-01-30
- Construct for LOINC Short Name
- Ceftolozane+Tazobactam
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 头孢洛林+他唑巴坦 Synonyms: 头孢洛林（头孢洛林酯、 |
| es-ES | Spanish (Spain) | Ceftolozane+Tazobactam |
| it-IT | Italian (Italy) | Ceftolozane+Tazobactam |
| tr-TR | Turkish (Turkey) | Seftolozan+Tazobaktam |
| ru-RU | Russian (Russian Federation) | Цефтолозан+Тазобактам |
| nl-NL | Dutch (Netherlands) | ceftolozaan + tazobactam |
| fr-FR | French (France) | Ceftolozane+tazobactam |
| el-GR | Greek (Greece) | Κεφτολοζάνη+Ταζομπακτάμη Synonyms: Κεφτολοζάνη+Ταζομπακτάμη |
LOINC Copyright
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