LP17260-8
Purkinje cells
Active
Descriptions
Purkinje cells (or Purkinje neurons) are a class of GABAergic neuron located in the cerebellar cortex.
These cells are some of the largest neurons in the human brain, with an intricately elaborate dendritic arbor, characterized by a large number of dendritic spines. Purkinje cells are found within the Purkinje layer in the cerebellum. Purkinje cells are aligned like dominos stacked one in front of the other. Their large dendritic arbors form nearly two dimensional layers through which parallel fibers from the deeper-layer granule cells pass. These parallel fibers make relatively weaker excitatory (glutamatergic) synapses to spines in the Purkinje cell dendrite, whereas climbing fibers originating from the inferior olivary nucleus in the medulla provide very powerful excitatory input to the proximal dendrites and cell soma.
In humans, Purkinje cells are affected in a variety of diseases ranging from toxic exposure (alcohol, lithium), to autoimmune diseases and to genetic mutations (spinocerebellar ataxias, Unverricht-Lundborg disease, autism) and neurodegenerative diseases that are not thought to have a known genetic basis (cerebellar type of multiple system atrophy, sporadic ataxias).
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Purkinje cells (Wikipedia)
The output neurons of the cerebellar cortex. Source: National Library of Medicine, MeSH 2006
Basic Part Properties
- Part Display Name
- Purkinje cells
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Purkinje Cells
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP17260-8
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 浦肯雅细胞 Synonyms: Purkinje 细胞; |
| fr-CA | French (Canada) | Cellules de Purkinje |
| et-EE | Estonian (Estonia) | Purkinje rakkude vastased |
| es-ES | Spanish (Spain) | Células de Purkinje |
| it-IT | Italian (Italy) | Cellule di Purkinje |
| tr-TR | Turkish (Turkey) | Purkinje hücreleri |
| ru-RU | Russian (Russian Federation) | Пуркинье клетки |
| nl-NL | Dutch (Netherlands) | purkinjecellen |
| fr-BE | French (Belgium) | Cellules de Purkinje |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright