Version 2.77

Description

4-Hydroxycoumarins are a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin (chromen-2-one). The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. The synthetic drugs in the 4-hydroxycoumarin class are all noted primarily for their use as anticoagulants, though they can have several additional effects. The simplest synthetic molecule in the 4-hydroxycoumarin class is warfarin, in which the aromatic 3-position substituent is a simple phenyl group. So called "super-warfarins" or second-generation anticoagulants in this class, were developed as rodenticides for rodents that have developed warfarin resistance. The second generation agents have even larger lipid-soluble substituents at the 3-position (e.g. brodifacoum), a chemical change that causes their half life in the body to be greatly increased (sometimes to months). The antirodenticide chemicals are sometimes incorrectly referred to as "coumadins" rather than 4-hydroxycoumarins (Coumadin is a brandname for warfarin). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, 4-hydroxycoumarins

Basic Part Properties

Part Display Name
4-hydroxycoumarins
Part Type
Component (Describes the core component or analyte measured)
Created On
2013-07-30
Construct for LOINC Short Name
4OH-coumarins

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 4-羟基香豆素类
Synonyms: 4-羟基香豆素;4-羟基香豆精类;4-羟基香豆精;4-羟香豆素类
es-ES Spanish (Spain) 4-hidroxicumarina
it-IT Italian (Italy) 4-idrossicumarina
tr-TR Turkish (Turkey) 4-Hidroksikumarinler
ru-RU Russian (Russian Federation) 4-гидроксикумарины
nl-NL Dutch (Netherlands) 4-hydroxycoumarinen