LP173607-5
4-hydroxycoumarins
Active
Description
4-Hydroxycoumarins are a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin (chromen-2-one). The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. The synthetic drugs in the 4-hydroxycoumarin class are all noted primarily for their use as anticoagulants, though they can have several additional effects. The simplest synthetic molecule in the 4-hydroxycoumarin class is warfarin, in which the aromatic 3-position substituent is a simple phenyl group. So called "super-warfarins" or second-generation anticoagulants in this class, were developed as rodenticides for rodents that have developed warfarin resistance. The second generation agents have even larger lipid-soluble substituents at the 3-position (e.g. brodifacoum), a chemical change that causes their half life in the body to be greatly increased (sometimes to months). The antirodenticide chemicals are sometimes incorrectly referred to as "coumadins" rather than 4-hydroxycoumarins (Coumadin is a brandname for warfarin). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, 4-hydroxycoumarins
Basic Part Properties
- Part Name
- 4-hydroxycoumarins
- Part Display Name
- 4-hydroxycoumarins
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2013-07-30
- Construct for LOINC Short Name
- 4OH-coumarins
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 4-羟基香豆素类 Synonyms: 4-羟基香豆素; |
| es-ES | Spanish (Spain) | 4-hidroxicumarina |
| it-IT | Italian (Italy) | 4-idrossicumarina |
| tr-TR | Turkish (Turkey) | 4-Hidroksikumarinler |
| ru-RU | Russian (Russian Federation) | 4-гидроксикумарины |
| nl-NL | Dutch (Netherlands) | 4-hydroxycoumarinen |
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