LP18494-2
Activated protein C resistance
Active
Descriptions
APC Resistance is a ratio of aPTT with APC to aPTT without APC. Source: Regenstrief Institute
A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC) which increases the risk of a clotting disorder. The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance. Source: National Library of Medicine, MeSH 2006
Activated protein C resistance (APC) has emerged as the most frequent abnormality in patients with idiopathic thrombosis. Patients found to be heterozygous for APC resistence have a seven fold increased risk for venous thrombosis as compared to the general popualtion. Homozygous individuals have an eight fold increased risk of thrombosis. Familial studies and counselling should be considered for positive patients. The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance. Often measured as the ratio of the Appt W APC. Source: Regenstrief Institute
Basic Part Properties
- Part Display Name
- Activated protein C resistance
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- aPCR
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 活化蛋白 C 抗性 Synonyms: APC 抗性; |
| fr-CA | French (Canada) | Résistance à la protéine C activée |
| et-EE | Estonian (Estonia) | Aktiveeritud proteiini C resistentsus |
| es-ES | Spanish (Spain) | Resistencia a la proteína C activada |
| it-IT | Italian (Italy) | Proteina C attivata, resistenza Synonyms: Resistenza alla proteina C attivata |
| tr-TR | Turkish (Turkey) | Aktiflenmiş protein C resistans |
| ru-RU | Russian (Russian Federation) | Активированный протеин С резистентность |
| nl-NL | Dutch (Netherlands) | geactiveerd proteïne C-resistentie |
| fr-BE | French (Belgium) | Résistance à la protéine C activée Synonyms: RPCa |
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