LP18544-4
Cortisone
Active
Descriptions
Cortisone is a downstream metabolite of cortisol. 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta HSD2) converts cortisol to cortisone. Like cortisol, cortisone has an important circadian rhythm where amounts peak in the morning and reach the lowest level late at night. Levels of cortisone, including urinary-free cortinsone, are useful in the diagnosis for acquired or inherited adrenal disorders due to a deficiency of 11-beta HSD enzymes and a non-functioning hypothalamus-pituitary-adrenal axis. Source: Regenstrief LOINC
Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma. Source: Regenstrief Help
Basic Part Properties
- Part Display Name
- Cortisone
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Cortisone
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 可的松 Synonyms: 17羟11脱氢皮甾酮; |
| fr-CA | French (Canada) | Cortisone |
| et-EE | Estonian (Estonia) | Kortisoon |
| es-ES | Spanish (Spain) | Cortisona |
| it-IT | Italian (Italy) | Cortisone |
| tr-TR | Turkish (Turkey) | Kortizon |
| ru-RU | Russian (Russian Federation) | Кортизон |
| nl-NL | Dutch (Netherlands) | cortison |
| fr-BE | French (Belgium) | Cortisone |
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