Version 2.77

Descriptions

Cortisone is a downstream metabolite of cortisol. 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta HSD2) converts cortisol to cortisone. Like cortisol, cortisone has an important circadian rhythm where amounts peak in the morning and reach the lowest level late at night. Levels of cortisone, including urinary-free cortinsone, are useful in the diagnosis for acquired or inherited adrenal disorders due to a deficiency of 11-beta HSD enzymes and a non-functioning hypothalamus-pituitary-adrenal axis. Source: Regenstrief LOINC

Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma. Source: Regenstrief Help

Basic Part Properties

Part Display Name
Cortisone
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
Cortisone

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP18544-4
ConceptMap translate
https://fhir.loinc.org/ConceptMap/$translate?system=http://loinc.org&code=LP18544-4

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 可的松
Synonyms: 17羟11脱氢皮甾酮;17-羟-11-脱氢皮甾酮;化合物 E
fr-CA French (Canada) Cortisone
et-EE Estonian (Estonia) Kortisoon
es-ES Spanish (Spain) Cortisona
it-IT Italian (Italy) Cortisone
tr-TR Turkish (Turkey) Kortizon
ru-RU Russian (Russian Federation) Кортизон
nl-NL Dutch (Netherlands) cortison
fr-BE French (Belgium) Cortisone