Version 2.78

Description

The RA disease activity score is determined by a multi-biomarker disease activity (MBDA) algorithm, which was developed in a series of studies and clinically validated using the DAS28-CRP as a standard. The MBDA algorithm is as follows:

PTJC = Prediction of Tender Joint Count = −26.72+3.243 × [YKL-40]1/10 − 11.97 × [EGF]1/10 + 15.72 × [IL-6]1/10 + 0.4594 × [Leptin]1/10 + 3.881 × [SAA]1/10 + 0.7388 × [TNF-RI]1/10 − 0.2557 × [VCAM-1]1/10 + 0.7003 × [VEGF-A]1/10

PSJC = Prediction of Swollen Joint Count = −26.63 + 3.232 × [YKL-40]1/10 − 11.93 × [EGF]1/10 + 15.67 × [IL-6]1/10 + 0.4578 × [Leptin]1/10 + 3.868 × [SAA]1/10 + 0.7363 × [TNF-RI]1/10 − 0.2548 × [VCAM-1]1/10 + 0.6979 × [VEGF-A]1/10

PPGS = Prediction of Patient Global Score = -13.489 + 5.474 × [IL-6]1/10 + 0.486 × [SAA]1/10 + 2.246 × [MMP-1]1/10 + 1.684 × [Leptin]1/10 + 4.14 × [TNF-RI]1/10 + 2.292 × [VEGF-A]1/10 − 1.898 × [EGF]1/10 + 0.028 × [MMP-3]1/10 − 2.892 × [VCAM-1]1/10 − 0.506 × [Resistin]1/10

MBDA score = round(max(min((0.56 × sqrt(max(PTJC,0)) + 0.28 × sqrt(max(PSJC,0)) + 0.14 × PPGS + 0.36 × log(CRP/106 + 1)) × 10.53 + 1, 100),1))

The biomarker concentrations in the above formulas are expressed in pg/mL. All concentration values (except CRP) are transformed to the power 1/10 prior to use in the algorithm. MBDA scores are integers from 1 to 100 where 1 to 29 are considered low disease activity, 30 to 44 are moderate disease activity, and 45 to 100 are high disease activity. PMID: 22749821 Source: NCBI PubMed, PMID: 22749821

Basic Part Properties

Part Display Name
Rheumatoid arthritis disease activity score
Part Type
Component (Describes the core component or analyte measured)
Created On
2014-08-13
Construct for LOINC Short Name
RA DAS

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP185753-3

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 类风湿性关节炎疾病活动度评分
Synonyms: 类风湿性关节炎（类风湿关节炎、RA）疾病活动度（活动）评分（分值、分数、得分）;类风湿性关节炎疾病活动指数;类风湿性关节炎 DAS;RA-DAS;DAS-RA
es-ES Spanish (Spain) Puntuación de actividad de la enfermedad artritis reumatoide
it-IT Italian (Italy) Artrite reumatoide, punteggio attività
Synonyms: Punteggio attività dell''artrite reumatoide
tr-TR Turkish (Turkey) Romatoid artrit hastalık aktivite skoru