Version 2.80

Description

The RA disease activity score is determined by a multi-biomarker disease activity (MBDA) algorithm, which was developed in a series of studies and clinically validated using the DAS28-CRP as a standard. The MBDA algorithm is as follows:

PTJC = Prediction of Tender Joint Count = −26.72+3.243 × [YKL-40]1/10 − 11.97 × [EGF]1/10 + 15.72 × [IL-6]1/10 + 0.4594 × [Leptin]1/10 + 3.881 × [SAA]1/10 + 0.7388 × [TNF-RI]1/10 − 0.2557 × [VCAM-1]1/10 + 0.7003 × [VEGF-A]1/10

PSJC = Prediction of Swollen Joint Count = −26.63 + 3.232 × [YKL-40]1/10 − 11.93 × [EGF]1/10 + 15.67 × [IL-6]1/10 + 0.4578 × [Leptin]1/10 + 3.868 × [SAA]1/10 + 0.7363 × [TNF-RI]1/10 − 0.2548 × [VCAM-1]1/10 + 0.6979 × [VEGF-A]1/10

PPGS = Prediction of Patient Global Score = -13.489 + 5.474 × [IL-6]1/10 + 0.486 × [SAA]1/10 + 2.246 × [MMP-1]1/10 + 1.684 × [Leptin]1/10 + 4.14 × [TNF-RI]1/10 + 2.292 × [VEGF-A]1/10 − 1.898 × [EGF]1/10 + 0.028 × [MMP-3]1/10 − 2.892 × [VCAM-1]1/10 − 0.506 × [Resistin]1/10

MBDA score = round(max(min((0.56 × sqrt(max(PTJC,0)) + 0.28 × sqrt(max(PSJC,0)) + 0.14 × PPGS + 0.36 × log(CRP/106 + 1)) × 10.53 + 1, 100),1))

The biomarker concentrations in the above formulas are expressed in pg/mL. All concentration values (except CRP) are transformed to the power 1/10 prior to use in the algorithm. MBDA scores are integers from 1 to 100 where 1 to 29 are considered low disease activity, 30 to 44 are moderate disease activity, and 45 to 100 are high disease activity. PMID: 22749821 Source: NCBI PubMed , PMID: 22749821

Basic Part Properties

Part Name
Rheumatoid arthritis disease activity score
Part Display Name
Rheumatoid arthritis disease activity score
Part Type
Component (Describes the core component or analyte measured)
Created On
2014-08-13
Construct for LOINC Short Name
RA DAS

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP185753-3

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Puntuación de actividad de la enfermedad artritis reumatoide
zh-CN Chinese (China) 类风湿性关节炎疾病活动度评分
Synonyms: 类风湿性关节炎（类风湿关节炎、RA）疾病活动度（活动）评分（分值、分数、得分）;类风湿性关节炎疾病活动指数;类风湿性关节炎 DAS;RA-DAS;DAS-RA
it-IT Italian (Italy) Artrite reumatoide, punteggio attività
Synonyms: Punteggio attività dell''artrite reumatoide
tr-TR Turkish (Turkey) Romatoid artrit hastalık aktivite skoru
el-GR Greek (Greece) Βαθμολογία ενεργότητας της νόσου της ρευματοειδούς αρθρίτιδας
Synonyms: Βαθμολογία ενεργότητας της νόσου της ρευματοειδούς αρθρίτιδας