LP18603-8
P53 protein
Active
Description
The p53 antigen was first discovered in 1979 and recognized as a tumor repressive gene in 1989. It encodes a protein that monitors the cell cycle by suppressing tumor growth and preventing genome mutation. When p53 is defective, abnormal cell proliferation can occur. Mutations in p53 are present in up to 50% of all human tumors. The three major functions of p53 include growth arrest, DNA repair, and apoptosis. P53 halts the growth arrest function of the cell cycle progress which can activate transcription of proteins that repair DNA. There are low levels of p53 in normal cells, but damage to DNA and similar stress signals may precipitate an increase of p53 protein. Cell death is the final course of action to prevent cells containing abnormal DNA from dividing. The concentration of P53 in cells is probably tightly controlled since high concentrations may accelerate aging due to excess apoptosis.
[http://www.bioinformatics.org/p53/introduction.html] Ongoing studies are investigating the utility of the p53 antibody being used as a biomarker for the early detection of lung cancer in high risk asymptomatic patients. PMID: 21733826
Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- P53 protein
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- P53 protein
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | P53 蛋白 Synonyms: p53 抗癌基因蛋白; |
| fr-CA | French (Canada) | Protéine P53 |
| et-EE | Estonian (Estonia) | P53 valk |
| es-ES | Spanish (Spain) | Proteína p53 |
| it-IT | Italian (Italy) | P53, proteina Synonyms: Proteina P53 |
| tr-TR | Turkish (Turkey) | P53 protein |
| ru-RU | Russian (Russian Federation) | P53 протеин |
| nl-NL | Dutch (Netherlands) | p53-eiwit |
| fr-BE | French (Belgium) | Protéine P53 |
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