Version 2.78

Description

Hepatocyte growth factor receptor (HGFR, also known as mesenchymal-epithelial transition (MET or c-MET]) is a transmembrane tyrosine kinase receptor that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. [UniProt: P08581] The HGFR is a product of the MET gene and is important to oncogenesis and normal cellular function. It regulates many physiological processes including proliferation, scattering, morphogenesis and survival. The HGFR can be overexpressed in epithelial cancers, such as lung cancer. The overexpression of c-MET is thought to allow for cell migration and invasion leading to metastasis as well as growth advantage. PMID: 24005867 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Hepatocyte growth factor receptor
Part Type
Component (Describes the core component or analyte measured)
Created On
2015-03-06
Construct for LOINC Short Name
HGFR

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP189738-0

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 肝细胞生长因子受体
Synonyms: HGFR;HGF-R
es-ES Spanish (Spain) Receptor del factor de crecimiento de hepatocitos
it-IT Italian (Italy) Recettore fattore di crescita degli epatociti
tr-TR Turkish (Turkey) Hepatosit büyüme faktörü reseptörü
nl-NL Dutch (Netherlands) hepatocyt groeifactorreceptor
pl-PL Polish (Poland) Receptor czynnika wzrosu hepatocytów
Synonyms: Receptor czynnika wzrosu hepatocytów