LP189752-1
4q12 chromosome region rearrangements
Active
Description
Chromosome region 4q12 rearrangements are associated with myeloid and lymphoid neoplasms due to disruption of the PDGFRA and/or FGFR1 genes. Patients with rearrangement(s) involving PDGFRA most commonly present with chronic eosinophilic leukemia but also can present as acute myeloid leukemia (AML) and/or T-lymphoblastic leukemia/lymphoma (T-ALL). Patients with FGFR1 involvement have various presentations including AML, T- or B-lymphoblastic leukemia/lymphoma (B-ALL), or a mixed phenotype acute leukemia. Imatinib mesylate (imatinib) is the first-line therapy for patients with abnormalities of PDGFRA, whereas patients with FGFR1 fusions are resistant to this therapy and carry a poor prognosis. PMID: 23489324 Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- 4q12 chromosome region rearrangements
- Part Display Name
- 4q12 chromosome region rearrangements
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-03-08
- Construct for LOINC Short Name
- 4q12 rearrange
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 4q12 染色体区域重排 Synonyms: 4q12 染色体区域（染色体部位、 |
| tr-TR | Turkish (Turkey) | 4q12 Kromozom bölgesi yeniden düzenleme |
| es-ES | Spanish (Spain) | reordenamientos cromosoma 4q12 |
| it-IT | Italian (Italy) | Riorganizzazioni della regione cromosomica 4q12 |
| nl-NL | Dutch (Netherlands) | 4q12-chromosoomgebied translocaties Synonyms: 4q12-chromosoom gebied translocaties |
| pl-PL | Polish (Poland) | Rearanżacja regionu chromosomu 4q12 |
| el-GR | Greek (Greece) | Αναδιατάξεις χρωμοσωμικής περιοχής 4q12 Synonyms: Αναδιατάξεις χρωμοσωμικής περιοχής 4q12 |
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