Version 2.78

Description

Dehydroaripiprazole is the active metabolite of the parent drug aripiprazole which is used to treat acute schizophrenia and other psychoses. Aripiprazole is metabolized to dehydroaripiprazole by the enzymes CYP3A4 and CYP2D6. PMID: 17853280 Dehydroaripiprazole binds with postsynaptic dopamine receptors and presynaptic autoreceptors, blocking dopamine from attaching to the receptors and preventing a postsynaptic response that is usually triggered by dopamine.[https://web.williams.edu/imput/synapse/pages/IIIB5.htm] The blood levels of dehydroaripiprazole vary widely between patients who have taken the same dose of the drug. Therapeutic monitoring is important to verify the patient's blood level is within the therapeutic range, to identify patients who are non-compliant in taking their medication, and to prevent drug toxicity. PMID: 22020350 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Dehydroaripiprazole
Part Type
Component (Describes the core component or analyte measured)
Created On
2015-03-16
Construct for LOINC Short Name
Dehydroaripiprazole

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 脱氢阿立哌唑
Synonyms: 脱氢阿立派唑;脱氢阿利哌唑
es-ES Spanish (Spain) Dehidroaripiprazol
it-IT Italian (Italy) Dehydroaripiprazolo
tr-TR Turkish (Turkey) Dehidroaripiprazol
nl-NL Dutch (Netherlands) dehydroaripiprazol