Version 2.78

Description

Lorazepam glucuronide is a major metabolite of lorazepam, a high-potency, intermediate-duration, 3-hydroxy benzodiazepine drug, often used to treat anxiety disorders. Lorazepam is rapidly conjugated at its 3-hydroxy group into lorazepam glucuronide which is then excreted in the urine. Lorazepam glucuronide has no demonstrable central nervous system (CNS) activity in animals. On discontinuation, lorazepam serum levels become negligible after three days and undetectable after about a week. Lorazepam-glucuronide is more water-soluble than its precursor, so gets more widely distributed in the body, leading to a longer half-life than lorazepam. Lorazepam-glucuronide is eventually excreted by the kidneys and, because of its tissue accumulation, remains detectable, particularly in the urine, for substantially longer than lorazepam.[Wikipedia: Lorazepam] Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Lorazepam

Basic Part Properties

Part Display Name
LORazepam glucuronide
Part Type
Component (Describes the core component or analyte measured)
Created On
2015-04-02
Construct for LOINC Short Name
LORazepam glucuronide

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP190318-8

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 葡萄糖苷酸劳拉西泮
Synonyms: 葡糖苷酸劳拉西泮;葡[萄]糖苷酸劳拉西泮;葡萄糖苷酸氯羟安定;葡萄糖苷酸氯羟二氮卓
it-IT Italian (Italy) Lorazepam glucuronide
es-ES Spanish (Spain) Glucurónido de lorazepam