LP19492-5
Thiopurine methyltransferase
Active
Description
Thiopurine methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs including 6-mercatptopurine, thioguanine, and azathioprine (AZA). These drugs are used to treat acute lymphoblastic leukemia, inflammatory bowel disease, rheumatoid arthritis, and organ transplant rejection. Patients with low or absent TPMT activity are at increased risk for toxicity due to increased accumulation of unmetabolised drug. Information from Current Clinical Pharmacology. 2006;1:119-128. Source: Regenstrief Institute
Basic Part Properties
- Part Display Name
- Thiopurine methyltransferase
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- TPMT
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 硫嘌呤甲基转移酶 Synonyms: TPMT; |
| fr-CA | French (Canada) | Thiopurine méthyltransférase |
| et-EE | Estonian (Estonia) | Tiopuriini metüültransferaas |
| es-ES | Spanish (Spain) | Tiopurina metiltransferasa |
| it-IT | Italian (Italy) | Tiopurina metiltransferasi |
| tr-TR | Turkish (Turkey) | Tiyopürin metiltransferaz |
| ru-RU | Russian (Russian Federation) | Тиопурин метилтрансфераза Synonyms: Тиопурин-S-метилтрансфераза |
| nl-NL | Dutch (Netherlands) | thiopurinemethyltransferase |
| fr-BE | French (Belgium) | Thiopurine méthyltransférase |
LOINC Copyright
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