LP19647-4
CDKN2B gene
Active
Description
The CDKN2B gene (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)) [HGNC Gene ID:1788] is located on chromosome 9p21. This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] [NCBI Gene ID:1030] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Name
- CDKN2B gene
- Part Display Name
- CDKN2B gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- CDKN2B gene
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | CDK2B 基因 Synonyms: CDK4B 抑制剂; |
| et-EE | Estonian (Estonia) | CDKN2B geen |
| es-ES | Spanish (Spain) | Gen CDKN2B |
| it-IT | Italian (Italy) | CDKN2B, gene Synonyms: Gene CDKN2B |
| tr-TR | Turkish (Turkey) | CDKN2B geni |
| ru-RU | Russian (Russian Federation) | CDKN2B ген |
| nl-NL | Dutch (Netherlands) | CDKN2B-gen Synonyms: CDKN2B gen |
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