Version 2.78

Description

The EGFR gene (epidermal growth factor receptor) [HGNC Gene ID:3236] is located on chromosome 7p12. The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010] [NCBI Gene ID:1956] Source: National Center for Biotechnology Information (NCBI) Gene

Reference Information

Type Source Reference
Webcontent Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. Link to OMIM

Basic Part Properties

Part Display Name
EGFR gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
EGFR gene

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP19695-3
ConceptMap translate
https://fhir.loinc.org/ConceptMap/$translate?system=http://loinc.org&code=LP19695-3

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) EGFR 基因
Synonyms: ERBB;ERBB1;V-ERB-B 禽类成红血细胞性白血病病毒性致癌基因同源基因;V-ERB-B 禽类成红血细胞性白血病病毒致癌基因同源基因;V-ERB-B 鸟类成红血细胞性白血病病毒性癌基因同源基因;V-ERB-B 鸟类成红血细胞性白血病病毒癌基因同源基因;癌基因 ERBB;致癌基因 ERBB;表皮生长因子受体基因
et-EE Estonian (Estonia) EGFR geen
es-ES Spanish (Spain) Gen EGFR
it-IT Italian (Italy) EGFR, gene
Synonyms: Gene EGFR
tr-TR Turkish (Turkey) EGFR geni
ru-RU Russian (Russian Federation) EGFR ген
nl-NL Dutch (Netherlands) EGFR-gen
Synonyms: EGFR gen