LP19697-9
F5 gene
Active
Descriptions
Factor V gene mutation causes APC resistance and is used as a confirmatory test for abornormal APC resistance. Source: Regenstrief Institute
The F5 gene (coagulation factor V (proaccelerin, labile factor)) [HGNC Gene ID:3542] is located on chromosome 1q23. This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008] [NCBI Gene ID:2153] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Display Name
- F5 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- F5 gene
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | F5 基因 Synonyms: APC; |
| fr-CA | French (Canada) | Gène F5 |
| et-EE | Estonian (Estonia) | F5 geen |
| es-ES | Spanish (Spain) | Gen F5 |
| it-IT | Italian (Italy) | F5, gene Synonyms: Gene F5 |
| tr-TR | Turkish (Turkey) | F5 geni |
| ru-RU | Russian (Russian Federation) | F5 ген |
| nl-NL | Dutch (Netherlands) | F5-gen Synonyms: f5 gen |
| fr-BE | French (Belgium) | Gène F5 |
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