Version 2.78

Description

The NRAS gene (neuroblastoma RAS viral (v-ras) oncogene homolog) [HGNC Gene ID:7989] is located on chromosome 1p13.2. This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] [NCBI Gene ID:4893] Source: National Center for Biotechnology Information (NCBI) Gene

Reference Information

Type Source Reference
Webcontent Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. Link to OMIM

Basic Part Properties

Part Display Name
NRAS gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
NRAS gene

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP19749-8
ConceptMap translate
https://fhir.loinc.org/ConceptMap/$translate?system=http://loinc.org&code=LP19749-8

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) NRAS 基因
Synonyms: v-ras 成神经细胞瘤 RAS 病毒癌基因同源基因;v-ras 神经母细胞瘤 RAS 病毒癌基因同源基因;癌基因 NRAS;致癌基因 NRAS
et-EE Estonian (Estonia) NRAS geen
es-ES Spanish (Spain) Gen NRAS
it-IT Italian (Italy) NRAS, gene
Synonyms: Gene NRAS
tr-TR Turkish (Turkey) NRAS geni
ru-RU Russian (Russian Federation) NRAS ген
nl-NL Dutch (Netherlands) NRAS-gen
Synonyms: NRAS gen