LP19770-4
TRAF3 gene
Active
Description
The TRAF3 gene (TNF receptor-associated factor 3) [HGNC Gene ID:12033] is located on chromosome 14q32.32. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010] [NCBI Gene ID:7187] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Name
- TRAF3 gene
- Part Display Name
- TRAF3 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- TRAF3 gene
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | TRAF3 基因 Synonyms: CAP1; |
| et-EE | Estonian (Estonia) | TRAF3 geen |
| es-ES | Spanish (Spain) | Gen TRAF3 |
| it-IT | Italian (Italy) | TRAF3, gene Synonyms: Gene TRAF3 |
| tr-TR | Turkish (Turkey) | TRAF3 geni |
| ru-RU | Russian (Russian Federation) | TRAF3 ген |
| nl-NL | Dutch (Netherlands) | TRAF3-gen Synonyms: TRAF3 gen |
LOINC Copyright
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