LP19774-6
CCND1 gene rearrangements
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Description
The CCND1 gene (cyclin D1) [HGNC Gene ID:1582] is located on chromosome 11q13. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008] [NCBI Gene ID:595] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Name
- CCND1 gene rearrangements
- Part Display Name
- CCND1 gene rearrangements
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- CCND1 gene Rear
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | CCND1 基因重排 Synonyms: CCND1 基因重排（重组） |
| et-EE | Estonian (Estonia) | CCND1 geeni muudatused |
| es-ES | Spanish (Spain) | Reordenamientos del gen CCND1 |
| it-IT | Italian (Italy) | CCND1, riarrangiamenti gene Synonyms: Riarrangiamenti gene CCND1 |
| tr-TR | Turkish (Turkey) | CCND1 geni yeniden düzenlemeler |
| ru-RU | Russian (Russian Federation) | CCND1 ген перестройки |
| nl-NL | Dutch (Netherlands) | CCND1-genherschikking Synonyms: CCND1 gen translocaties |
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