Version 2.78

Description

Translocation (8;21) resulting in a fused transcript between RUNX1T1 (also known as ETO) and RUNX1 genes is one of the most common chromosomal translocations found in acute myeloid leukemia (AML). The RUNX1T1-RUNX1 fusion transcript is found in approximately 12% of all AML patients. RUNX1 is a transcription factor that regulates critical processes in many aspects of hematopoiesis and is essential in defining the final hematopoietic stem cell. It is involved in many forms of chromosomal translocations in leukemia. In addition, many hematological diseases have been associated with mutations in RUNX1. PMID: 22201794 Source: Regenstrief LOINC, PMID: 22201794

Basic Part Properties

Part Display Name
t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
t(8;21)(RUNX1T1,RUNX1)

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP19847-0

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)
Synonyms: T(8,21)(CBFA2T1,CBFA2) 基因易位;T(8,21)(CBFA2T1,CBFA2) 易位
et-EE Estonian (Estonia) t(8,21)(CBFA2T1,CBFA2) translokatsioon
es-ES Spanish (Spain) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)
it-IT Italian (Italy) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)
tr-TR Turkish (Turkey) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)
ru-RU Russian (Russian Federation) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)
nl-NL Dutch (Netherlands) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)
fr-CA French (Canada) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)