Version 2.74


Leptospira is a flexible, spiral-shaped, Gram-negative spirochete with internal flagella. Leptospira interrogans has many serovars based on cell surface antigens. Most leptospirosis infections initially present with an acute onset of fever, headache and muscle pain, which symptoms last about a week. The three organ systems most frequently involved with more significant illness are the central nervous system, kidneys, and liver, and jaundice occurs with severe infections. With the appearance of antileptospiral antibodies, the acute phase of the disease subsides and leptospires can no longer be isolated from the blood. The disease is usually biphasic, with the acute phase followed by an immune phase, which occurs after an asymptomatic period of several days. The immune phase is associated with fever and central nervous system involvement, specifically meningitis. Leptospires appear in the urine during this phase and are shed for various periods depending on the host. Severe leptospirosis is associated with progressive impairment of hepatic and renal function, and renal failure is the most common cause of death.
Leptospirosis is a worldwide zoonosis with a variety of animal hosts. The primary reservoir is wild animals such as rodents, which can shed leptospires throughout their lifetimes. Domestic animals are also an important source of human infections. The disease is more widespread in tropical countries. Direct or indirect contact with urine containing virulent leptospires is the major means by which leptospirosis is transmitted.
Leptospira species, which include L. interrogans, L. autumnalis, L. borgpetersenii, and L. weili are further divided into more than 200 serotypes based on their antigenic composition. The more severe form of leptospirosis is frequently associated with the icterohaemorrhagiae serotype and is often referred to as Weil's disease. [NCBI Books: NBK8451] Source: Regenstrief LOINC, NCBI Books: NBK8451

Different strains of Leptospira have different degrees of virulence. L. interrogans serovar Copenhageni frequently results in life-threatening infections that are associated with jaundice, kidney injury and hemorrhage. The host of the Copenhageni serovar is Rattus norvegicus, which is also the host of other strains of Leptospira that are less virulent. [PMID: 26518696] The majority of human leptospirosis infections in Brazil are due to L. interrogans serovar Copenhageni. [PMID: 24098496] Source: Regenstrief LOINC, PMID: 24098496

Basic Part Properties

Leptospira interrogans serovar Copenhageni
Part Type
Component (Describes the core component or analyte measured)
Created On
Construct for LOINC Short Name
L inter Copen

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Language Variants

Tag Language Translation
zh-CN Chinese (China) 致病性钩端螺旋体 Copenhageni 血清型变种
Synonyms: Copenhageni 型致病性钩端螺旋体;Copenhageni 血清型变种(血清变型、血清变异株、血清变种)致病性钩端螺旋体;致病性钩端螺旋体 Copenhageni 型;钩体;问号钩端螺旋体
fr-CA French (Canada) Leptospira interrogans serovar Copenhageni
es-ES Spanish (Spain) Leptospira interrogans serotipo Copenhageni
it-IT Italian (Italy) Leptospira interrogans sierotipo Copenhageni
Synonyms: Leptospira interrogans serovar Copenhageni
tr-TR Turkish (Turkey) Leptospira interrogans serovar Copenhageni
ru-RU Russian (Russian Federation) Leptospira interrogans серовар Copenhageni
nl-NL Dutch (Netherlands) Leptospira interrogans serotype Copenhageni
fr-BE French (Belgium) Leptospira interrogans serovar Copenhageni