LP200579-3
S-adenosylhomocysteine
Active
Description
S-Adenosylhomocysteine (SAH) is formed by the demethylation of S-adenosylmethionine (SAMe) and is rapidly metabolized to homocysteine. The reaction of SAH to homocysteine is catalyzed by S-adenosylhomocysteine hydrolase and is reversible with the equilibrium favoring formation of SAH. Therefore, increased levels of SAH may occur when the intracellular concentration of homocysteine increases. Since SAH is known to inhibit methylation dependent reactions, the ratio of SAMe to SAH is often used as an index of methylation status. Disturbances in the transmethylation pathway indicated by abnormal SAMe, SAH or their ratio have been reported in many neurodegenerative diseases, such as dementia, depression or Parkinson's disease. PMID: 17892439 Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- S-adenosylhomocysteine
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-10-06
- Construct for LOINC Short Name
- SAH
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | S-腺苷同型半胱氨酸 Synonyms: S-腺苷基同型半胱氨酸; |
| es-ES | Spanish (Spain) | S-adenosilhomocistina |
| it-IT | Italian (Italy) | S-adenosilomocisteina |
| tr-TR | Turkish (Turkey) | S-adenozilhomosistein |
| nl-NL | Dutch (Netherlands) | S-adenosylhomocysteïne |
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