LP200582-7

Amisulpride

Active

Description

Amisulpride is a derivative of substituted benzamide and a second generation antipsychotic drug used to treat chronic schizophrenia. Low doses of amisulpride promote neurotransmission by blocking presynaptic dopamine autoreceptors D2 and D3. High doses of amisulpride reduce dopaminergic transmission by binding the postsynaptic dopamine D2 and D3 receptors more favorably in the limbic system. PMID: 11735643Blocking the postsynaptic D2 and D3 receptors in the limbic system is highly prognostic of powerful antipsychotic activity. Some data suggests that amisulpride is also effective in patients with dysthymia. Side effects to amisulpride include a low incidence of cardiac toxicity, hypotension, sedation, anticholinergic symptoms, weight gain and extrapyramidal side effects.[http://medind.nic.in/daa/t07/i2/daat07i2p140.pdf] Source: Regenstrief LOINC

Basic Part Properties

Part Name

Amisulpride

Part Display Name

Amisulpride

Part Type

Component (Describes the core component or analyte measured)

Created On

2015-10-06

Construct for LOINC Short Name

Amisulpride

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