LP201235-1
Extraocular retinoblastoma classification
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Description
The Reese-Ellsworth extraocular retinoblastoma staging system applies to cancer that has spread outside of the eye, either to the tissues around the eye or to the central nervous system (CNS), bone marrow, or lymph nodes. This staging system is based on how much cancer remains after surgery to remove the tumor and whether the cancer has spread. Details of each stage in the extraocular staging system are as follows:
Stage 0 (zero) - the cancer is in the eye (called intraocular) and has not spread outside of the eye. Most retinoblastoma cases are discovered in Stage 0 and should be classified based on the International Classification for Intraocular Retinoblastoma (ICRB). Doctors recommend conservative treatment for this stage with no additional adjuvant therapy, meaning no additional treatment after surgery.
Stage I - the eye has already been removed and there is some microscopic spread to the optic nerve. These patients need adjuvant chemotherapy after surgery.
Stage II - the tumor has spread to the optic nerve or the sclera, which is the white part of the eye. Patients with this stage need adjuvant chemotherapy and possibly radiation therapy.
Stage III - the cancer has spread to the lymph nodes or the bony cavity that surrounds the eyeball. Stage III is divided into two substages called stage IIIa and stage IIIb, depending on where the tumor has spread. The treatment for this stage involves both chemotherapy and radiation therapy.
Stage IV - the tumor has spread to distant areas of the body outside the eye, via the lymphatic system and blood vessels. Stage IV is divided into substages called IVa and IVb, and IVb is further divided into IVb1, IVb2, and IVb3, depending on the location of the spread. This stage of extraocular retinoblastoma is treated with high-dose chemotherapy followed by stem cell rescue. Radiation therapy may also be used in addition to high-dose chemotherapy for some patients with stage IV disease.
[http://www.cancer.gov/types/retinoblastoma/patient/retinoblastoma-treatment-pdq#link/stoc_h2_1]
Source: National Cancer Institute,
Basic Part Properties
- Part Display Name
- Extraocular retinoblastoma classification
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-10-12
- Construct for LOINC Short Name
- Extraocular RB class
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Language Variants Get Info
Tag | Language | Translation |
---|---|---|
zh-CN | Chinese (China) | 眼外视网膜母细胞瘤分类 Synonyms: 眼外(眼外期)视网膜母细胞瘤(成视网膜细胞瘤、 |
it-IT | Italian (Italy) | Classificazione del retinoblastoma extraoculare |
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