LP201688-1
N6-Acetyl-L-lysine
Active
Description
N-acetyl-lysine is an acetylated amino acid. Post-translational lysine-acetylation is one of two major modifications of lysine residues in various proteins. Acetylation of specific lysine residues in the N-terminal domains of core histones is a biochemical marker of active genes. Acetylation is now known to play a major role in eukaryotic transcription. Specifically, acetyltransferase enzymes that act on particular lysine side chains of histones and other proteins are intimately involved in transcriptional activation. By modifying chromatin proteins and transcription-related factors, these acetylases are believed to regulate the transcription of many genes. The best-characterized mechanism is acetylation, catalyzed by histone acetyltransferase (HAT) enzymes. HATs function enzymatically by transferring an acetyl group from acetyl-coenzyme A (acetyl-CoA) to the -amino group of certain lysine side chains within a histone's basic N-terminal tail region. Within a histone octamer, these regions extend out from the associated globular domains, and in the context of a nucleosome, they are believed to bind the DNA through charge interactions (positively charged histone tails associated with negatively charged DNA) or mediate interactions between nucleosomes. Lysine acetylation, which neutralizes part of a tail region's positive charge, is postulated to weaken histone-DNA or nucleosome-nucleosome interactions and/or signal a conformational change, thereby destabilizing nucleosome structure or arrangement and giving other nuclear factors, such as the transcription complex, more access to a genetic locus. In agreement with this is the fact that acetylated chromatin has long been associated with states of transcriptional activation. Specific recognition of N-acetyl-lysine is a conserved function of all bromodomains found in different proteins, recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization. PMID: 9169194 PMID: 10827952 PMID: 17340003 PMID: 16247734 PMID: 9478947 PMID: 10839822 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database ,
Basic Part Properties
- Part Name
- N6-Acetyl-L-lysine
- Part Display Name
- N6-Acetyl-L-lysine
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-10-22
- Construct for LOINC Short Name
- N6-Ac-L-lys
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | N6-乙酰-L-赖氨酸 Synonyms: N6-乙酰基-L-赖氨酸 |
| tr-TR | Turkish (Turkey) | N6-Astil-L-lizin |
| es-ES | Spanish (Spain) | N6-Acetil-L-lisina |
| it-IT | Italian (Italy) | N6-Acetil-L-lisina |
| nl-NL | Dutch (Netherlands) | N6-acetyl-L-lysine |
| el-GR | Greek (Greece) | Ν6-ακετυλο-L-λυσίνη Synonyms: Ν6-ακετυλο-L-λυσίνη |
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