LP202926-4
UGT1A1 gene product metabolic activity interpretation
Active
Description
UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 [HGNC Gene ID: 12530] gene. UDP-glucuronosyltransferase enzymes are part of the glucuronidation pathway that transforms small lipophilic molecules, such as irinotecan, into water-soluble, excretable metabolites. Reduced hepatic UGT1A1 activity to approximately 30% of normal is a hallmark of Gilbert syndrome, a benign condition characterized by mild unconjugated hyperbilirubinemia. Individuals with Gilbert syndrome may experience transient elevations in unconjugated plasma bilirubin in response to various triggers (e.g., fasting, infection, or medications). Genotypes most commonly implicated in Gilbert syndrome are UGT1A1*28/*28 and UGT1A1*6/*6. Genetic variations in UGT1A1 can also affect the response (i.e., efficacy or toxicity) to drugs metabolized by UGT1A1 (e.g., irintotecan) or that inhibit UGT1A1 function (e.g., atazanavir). Selection of alternative dosing or agents may be necessary in individuals with certain UGT1A1 genetic variations. PMID: 26417955 See https://www.pharmgkb.org/gene/PA420 for more information and dosing guidelines for drugs impacted by UGT1A1 genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium
Basic Part Properties
- Part Display Name
- UGT1A1 gene product metabolic activity interpretation
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-11-09
- Construct for LOINC Short Name
- UGT1A1 gene prod met act imp
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP202926-4
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | UGT1A1 基因产物新陈代谢活性解释 Synonyms: UGT1A1 基因产物新陈代谢（代谢）活性解释（说明、 |
| es-ES | Spanish (Spain) | Gen UGT1A1 interpretation de la actividad en el metabolismo de fármacos |
| it-IT | Italian (Italy) | Interpretazione dell'attività metabolica del gene UGT1A1 |
| tr-TR | Turkish (Turkey) | UGT1A1 geni ürünü metabolik aktivite yorumu |
| nl-NL | Dutch (Netherlands) | UGT1A1-gen product metabole activiteit interpretatie Synonyms: UGT1A1 gen product metabole activiteit interpretatie |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright