LP206581-3
Influenza virus A M gene
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Descriptions
The matrix protein gene of influenza virus A encodes two proteins: a matrix protein (M1) and an ion channel protein (M2). M1 plays a critical role in virus structure and replication by building connections between the viral lipid membrane and ribonucleoprotein (RNP) core. M1 also binds to RNPs in the nucleus, inhibiting viral transcription. The ion channel (M2) protein spans the lipid bilayer. Source: Regenstrief LOINC
The influenza virus A (FLUVA) genome is composed of eight gene segments (PB2, PB1, PA, HA, NP, NA, M, NS1) that code for 11 proteins. Two of the genes, hemagglutinin (HA) and neuraminidase (NA), determine the structure of the two primary surface proteins of influenza viruses. The HA and NA gene sequences are used to determine the Influenza virus subtype. Currently there are 16 subtypes of HA and 9 subtypes of NA known, but only H 1, 2 and 3, and N 1 and 2 are commonly found in humans. PMID: 17458769 The M gene segment, which encodes two matrix proteins (M1 and M2), may also be used as a target in PCR-based assays for detection of FLUVA in various specimens. Source: Regenstrief LOINC
The influenza A virus (FLUAV) is a common respiratory virus that infects humans as well as birds, horses, seals, dogs, and pigs. There are eight gene segments that make up the negative single-stranded RNA of the FLUAV. The gene segments are known as PB1, PB2, PA, NP, HA, NA, M, and NS. The M gene is the seventh segment and encodes the M1 (matrix protein) and M2 (membrane) proteins. [https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-6-67] The M1 protein is located beneath the lipid membrane and functions to give support and strength to the viral envelope. The M2 transmembrane protein is an ion channel that assists to uncover the virus once it is inside the host cell. M1 and NP proteins together determine whether the influenza virus is type A, B, or C. M1 brings viral constituents together to the assembly location, playing important roles in the creation of viral particles and in the budding process.[http://www.clinlabnavigator.com/influenza-virus-subtypes.html] Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- Influenza virus A M gene
- Part Display Name
- Influenza virus A M gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2016-01-05
- Construct for LOINC Short Name
- FLUAV M gene
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 流感病毒 A 型 M 基因 Synonyms: 流行性感冒病毒 A 型 M 基因; |
| es-ES | Spanish (Spain) | Genes A+B Metapneumovirus humano |
| it-IT | Italian (Italy) | Virus Influenza A gene M |
| nl-NL | Dutch (Netherlands) | Influenzavirus A M-gen Synonyms: Influenza virus A M gen |
| pl-PL | Polish (Poland) | Influenza wirus A gen M Synonyms: Gen M wirusa grypy typu A |
LOINC Copyright
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