Version 2.78

Description

Cryoglobulins are immunoglobulins that precipitate as serum is cooled below core body temperatures. Cryoglobulinemia is characterized by the presence of cryoglobulins in the serum. Single-component cryoglobulins contain only one isotype of immunoglobulin or, in rare instances, a cryoprecipitable monoclonal immunoglobulin light chain. Mixed cryoglobulins are immune complexes made of two different types of immunoglobulin, usually an IgM antiglobulin and IgG antigen. The classification initially proposed (Brouet et al) describes simple cryoglobulins as type I, and sub-divides mixed cryoglobulins as type II, in which case the antiglobulin is typically monoclonal, and type III, in which the antiglobulin is polyclonal. Some disorders associated with Type I are: multiple myeloma, Waldenstrom's macroglobulinemia, and other lymphoproliferative diseases. Type II may be associated with: chronic hepatitis C virus infection, Sjogren's syndrome, Waldenstrom's macroglobulinemia, chronic lymphocytic leukemia, non-Hodgkins' lymphoma, autoimmune diseases. Type III may be associated with: chronic infections, viral (EBV, CMV, HIV, hepatitis viruses), bacterial (SBE, leprosy, spirochetal), fungal, parasitic, autoimmune diseases, systemic lupus erythematosus (SLE), rheumatoid arthritis, inflammatory bowel diseases, and biliary cirrhosis. Screening for complement levels is done by quantitating antigenic levels of C3 and C4 and determining total hemolytic complement (CH50). Very low or undetectable levels of C4 with normal or relatively normal levels of C3 are often seen in type II cryoglobulinemia, and may suggest this diagnosis or a need for further workup for HCV infection. Low complement levels may also be seen in association with type II cryoglobulinemia complicating Sjogren's syndrome or with type III cryoglobulinemia in patients with rheumatoid vasculitis or SLE. Source: Regenstrief LOINC, PMID: 10050784

Basic Part Properties

Part Display Name
Cryoglobulin IgA and IgG and IgM and C3 panel
Part Type
Component (Describes the core component or analyte measured)
Created On
2016-02-25
Construct for LOINC Short Name
Cryo IgA + IgG + IgM + C3 Pnl

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP207797-4

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 冷球蛋白 IgA 与 IgG 与 IgM 与 C3 组套
Synonyms: 冷球蛋白（冷凝蛋白质、冷沉淀、冷沉淀物、冷沉淀球蛋白、冷沉球蛋白） IgA 与 IgG 与 IgM 与 C3 组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）
es-ES Spanish (Spain) Panel de crioglobulinas IgG, IgA e IgM
it-IT Italian (Italy) Crioglobulina IgA & IgG & IgM & C3 panel
Synonyms: Panel Crioglobulina IgA, IgG,IgM e C3
nl-NL Dutch (Netherlands) cryoglobuline IgA & IgG & IgM & C3 panel
pl-PL Polish (Poland) Krioglobulina IgA & IgG & IgM & C3 panel
Synonyms: Panel krioglobulin IgA i IgG i IgM i C3