LP208607-4
Chromosome painting analysis
Active
Descriptions
Whole chromosome painting probes are collections of smaller probes that bind to a different sequence along the length of a given chromosome. Using multiple probes labeled with a mixture of different fluorescent dyes, each chromosome is "painted" using its own unique color, and the resulting full-color map of the chromosome is called a spectral karyotype. Chromosome painting probes are useful for examining complex chromosomal structural aberrations, for example, translocations or subtle rearrangements. [https://www.genome.gov/10000206] Source: Regenstrief LOINC, National Human Genome Research Institute: Fluorescent in situ hybridization
Complex chromosome structural alterations can be detected by using cytogenetic methods such as chromosome painting analysis. Spectral karyotyping (SKY) and multiplex (M)-FISH are two types of chromosome painting methods. Both involve "painting" each chromosome a different color using 24 unique fluorochromes and then using the colors to identify subtle structural variations that previously could not be detected. According to one study, M-FISH has been able to identify chromosome abnormalities in up to 7% of patients with previously unexplained mental retardation. Complex structural aberration analysis can be the next step in evaluation when an abnormality is detected but cannot be further identified using more common methods, and the advanced methodologies are being utilized in different domains, including prenatal diagnosis as well as solid and hematologic malignancies. PMID: 12360235 Source: Regenstrief LOINC, PMID: 12360235
Basic Part Properties
- Part Display Name
- Chromosome painting analysis
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2016-03-30
- Construct for LOINC Short Name
- Chr paint
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP208607-4
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 染色体涂染分析 Synonyms: 染色体涂染技术; |
| es-ES | Spanish (Spain) | Analisis del mapa cromosómico |
| it-IT | Italian (Italy) | Analisi cromosomica con tecnica painting |
| pl-PL | Polish (Poland) | Malowanie chromosomów Synonyms: Analiza przez malowanie chromosomów |
LOINC Copyright
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