Version 2.78

Description

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, also known as phosphate and tensin homolog or PTEN protein, is encoded by the PTEN gene on chromosome10q23.31. PTEN protein has multiple functions, including protein phosphatase and lipid phosphatase activity. The lipid phosphatase function is critical for its role as a tumor suppressor and modulating cell cycle progression and cell survival. It also plays a role in correct neuron positioning, dendritic development and synapse formation, and may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. Mutations in the PTEN gene are associated with multiple disorders, including PTEN hamartoma tumor syndromes, which include Cowden syndrome and Lhermitte-Duclos disease, squamous cell carcinoma of the head and neck, endometrial carcinoma, prostate cancer, and VACTERL with hydrocephalus. [UniProt: P60484] Loss of the PTEN gene can be determined by various techniques, including FISH, and loss of the PTEN protein can be detected by immunohistochemistry techniques. Source: Regenstrief LOINC, UniProt: P60484

Basic Part Properties

Part Display Name
Phosphatase and tensin homolog (PTEN) protein
Part Type
Component (Describes the core component or analyte measured)
Created On
2016-04-29
Construct for LOINC Short Name
PTEN protein

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP212218-4

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 磷脂酰肌醇 3,4,5-三磷酸 3-磷酸酯酶与双特异性蛋白磷酸酯酶 PTEN
Synonyms: 磷脂酰肌醇（PI、磷脂酰环己六醇、磷脂酰肌、磷脂酰肌醇） 3,4,5-三磷酸 3-磷酸酯酶（磷酸酶）与双特异性（双重特异性）蛋白磷酸酯酶（磷酸酶） PTEN
es-ES Spanish (Spain) Fosfatidilinositol 3,4,5-trifosfato 3-fosfatasa y especificidad dual de proteinfosfatasa PTEN
it-IT Italian (Italy) Fosfatidilinositolo 3,4,5- trifosfato 3-fosfato e proteina PTEN fosfatasi a doppia specificità
nl-NL Dutch (Netherlands) fosfatidylinositol-3,4,5-trisfosfaat-3-fosfatase en duaal-specificiteit-proteïnefosfatase PTEN