Version 2.77

Descriptions

Lyme disease is a multisystem, multistage infection caused by three species of tick-borne spirochetes in the Borrelia burgdorferi sensu lato genogroup. These spirochetes include B. burgdorferi sensu stricto (North America and Western Europe), B. afzelii (Central and Western Europe and Russia), and B. garinii (Europe, Russia, and northern Asia). Endemic areas for Lyme disease in the United States correspond with the distribution of two tick species, Ixodes dammini (Northeastern and Upper Midwestern US) and Ixodes pacificus (West Coast US). In Europe, Ixodes ricinus transmits the spirochete. Human Lyme borreliosis, the most prevalent arthropod-borne infection in temperate climate zones around the world, is an inflammatory disorder characterized by the skin lesion erythema migrans and the potential development of neurologic, cardiac, and joint abnormalities. B. garinii, the most neurotropic of these three genospecies, causes most neurologic Lyme disease in Europe, including cases of meningopolyneuritis and, rarely, encephalomyelitis. Although probably all three genospecies can cause all major manifestations, it appears that infection with different B. burgdorferi sensu lato genospecies results in distinct presentations of Lyme borreliosis. In Europe, B. afzelii is mostly associated with skin manifestations, such as erythema migrans, and acrodermatitis chronica atrophicans, whereas B. garinii is the main cause of Lyme neuroborreliosis. Patients with B. garinii isolated from CSF samples have a distinct clinical presentation, compared with that of patients with B. afzelii infection. PMID: 16912943 PMID: 12454161 Source: Regenstrief LOINC

The oppA1 gene is a member of a family of three genes; oppA-1, oppA-2, and oppA-3, that encode predicted peptide-binding proteins. Peptide-binding protein dependent transport systems are recognized to play important roles in microbial cell signaling and virulence. PMID: 9712756 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Borrelia garinii+afzelii oppA1 gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2016-07-12
Construct for LOINC Short Name
B gar+afz oppA1

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP220480-0

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 加里疏螺旋体+阿夫塞疏螺旋体 oppA1 基因
Synonyms: 加里疏螺旋体（加里螺旋体菌、伽里疏螺旋体、加林螺旋体菌、伽里尼疏螺旋体、伽氏疏螺旋体、Garinii 疏螺旋体）+阿夫塞疏螺旋体（Afzelii 疏螺旋体、Afzelii 螺旋体、阿氏疏螺旋体、Afzelii 包柔氏螺旋体） oppA1 基因;中国莱姆病螺旋体;莱姆病;莱姆病螺旋体
es-ES Spanish (Spain) Gen oppA1 de Borrelia garinii+afzelii
it-IT Italian (Italy) Borrelia garinii+afzelii (oppA1), gene
Synonyms: Gene Borrelia garinii+afzelii (oppA1)
nl-NL Dutch (Netherlands) Borrelia garinii + afzelii oppA1-gen
Synonyms: borrelia garinii+afzelii (oppA1) gen