LP221212-6
Cells.programmed cell death ligand 1
Active
Description
Programmed cell death-ligand 1 (PD-L1), also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a protein that in humans is encoded by the CD274 gene. PD-L1 is the major ligand for the programmed cell death-1 (PD-1) receptor, which is present on the surface of T, B and NK cells and is part of the B7-CD28 superfamily. Binding PD-L1 and PD-L2 to the PD-1 receptor found on T-cells inhibits T cell proliferation and cytokine production. An increase PD-L1 expression occurs in some tumors, which helps protect them against active T-cell immune surveillance by binding to PD-1 and inhibiting the T-cell response. Positive PD-L1 immunohistochemistry in tumor cells may predict tumor response to therapy with immune checkpoint inhibitors, which are a new class of drugs that trigger an immune response against cancer cells by effectively suppressing the tumor's ability to inhibit the immune response. PMID: 25682184 Drugs in this class include pembrolizumab and nivolumab, both of which are anti-PD-1 receptor antibodies, and atezolizumab, which is an anti-PD-L1 antibody. PD-L1 may be a prognostic, diagnostic, and therapeutic marker in a variety of neoplasms, including carcinomas of the bladder, lung, and kidney. Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- Cells.programmed cell death ligand 1
- Part Display Name
- Cells.programmed cell death ligand 1
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2016-08-03
- Construct for LOINC Short Name
- Cells.PD-L1
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Células. Muerte celular programada del ligando 1 |
| zh-CN | Chinese (China) | 细胞.程序性死亡配体 1 Synonyms: 细胞.程序性死亡配体-1; |
| nl-NL | Dutch (Netherlands) | cellen.geprogrammeerde celdood ligand 1 |
| it-IT | Italian (Italy) | Cellule.morte cellulare programmata ligando 1 Synonyms: PD-L1 |
| pl-PL | Polish (Poland) | Komórki.ligand 1 programowanej śmierci komórki Synonyms: Ligand receptora programowanej śmierci 1 |
| el-GR | Greek (Greece) | Κύτταρα.συνδέτης προγραμματισμένου κυτταρικού θανάτου 1 Synonyms: Κύτταρα.συνδέτης προγραμματισμένου κυτταρικού θανάτου 1 |
LOINC Copyright
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