Version 2.77

Description

Programmed cell death-ligand 1 (PD-L1), also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a protein that in humans is encoded by the CD274 gene. PD-L1 is the major ligand for the programmed cell death-1 (PD-1) receptor, which is present on the surface of T, B and NK cells and is part of the B7-CD28 superfamily. Binding PD-L1 and PD-L2 to the PD-1 receptor found on T-cells inhibits T cell proliferation and cytokine production. An increase PD-L1 expression occurs in some tumors, which helps protect them against active T-cell immune surveillance by binding to PD-1 and inhibiting the T-cell response. Positive PD-L1 immunohistochemistry in tumor cells may predict tumor response to therapy with immune checkpoint inhibitors, which are a new class of drugs that trigger an immune response against cancer cells by effectively suppressing the tumor's ability to inhibit the immune response. PMID: 25682184 Drugs in this class include pembrolizumab and nivolumab, both of which are anti-PD-1 receptor antibodies, and atezolizumab, which is an anti-PD-L1 antibody. PD-L1 may be a prognostic, diagnostic, and therapeutic marker in a variety of neoplasms, including carcinomas of the bladder, lung, and kidney. Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Cells.programmed cell death ligand 1
Part Type
Component (Describes the core component or analyte measured)
Created On
2016-08-03
Construct for LOINC Short Name
Cells.PD-L1

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP221212-6

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 细胞.程序性死亡配体 1
Synonyms: 细胞.程序性死亡配体-1;细胞.PD-L1
es-ES Spanish (Spain) Células. Muerte celular programada del ligando 1
it-IT Italian (Italy) Cellule.ligando 1 di morte cellulare programmata
Synonyms: PD-L1
nl-NL Dutch (Netherlands) cellen.geprogrammeerde celdood ligand 1
pl-PL Polish (Poland) Komórki.ligand 1 programowanej śmierci komórki
Synonyms: Ligand receptora programowanej śmierci 1