Version 2.77

Description

Melanoma differentiation-associated gene 5 (MDA5) senses intracellular pathogens. Through a complex cascade of intracellular interactions with a myriad of activators and regulators MDA5 contributes to the production of interferon-alpha and pro-inflammatory chemokines and cytokines. Antibodies to MDA5 have been linked to a subtype of dermatomyositis (DM) associated with low-grade to absent muscle inflammation, acute skin manifestations, hyperferritinemic status, frequent and rapidly progressive interstitial lung disease (ILD) and a poor prognosis.( https://clinicalmolecularallergy.biomedcentral.com/articles/10.1186/s12948-015-0031-y) Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
MDA5 IgG
Part Type
Component (Describes the core component or analyte measured)
Created On
2016-10-05

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP230511-0

Language Variants Get Info

Tag Language Translation
pl-PL Polish (Poland) MDA5 Ab.IgG
Synonyms: PrzeciwciaƂa IgG do MDA5