Version 2.77


SynF is a capsule biosynthesis gene that uniquely identifies Neisseria meningitidis serogroup Y from the other meningococcal serogroups.[] There has been a large increase in the proportion of meningococcal disease caused by N. meningitidis serogroup Y since 1989. In the mid-1990s, the incidence increased substantially in the United States (US) and during the past 10 years, it has also increased in Canada, Columbia and Norway. A potential cause of this shift is the fact that the polysaccharide capsule based vaccine formulated for serogroups A, C, W-135 and Y is ineffective against children under 2 years of age and has only been useful for outbreaks of the disease. Recent vaccines for serogroups A and C have proven to be more effective in that age group which has led to serogroup Y being the most likely cause of pneumonia from Neisseria meningitidis. Diagnosis can be confirmed with positive blood, CSF or pleural fluid cultures. PMID: 26057210 Source: Regenstrief LOINC

Neisseria meningitidis is identified based on the species-specific targets sodC and ctrA. Individual Neisseria meningitidis serogroups are identified based on their serogroup-specific genes for capsule biosynthesis. Serogroups and the genes that identify them are as follows:
N. meningitidis serogroup A: sacB
N. meningitidis serogroup B: synD
N. meningitidis serogroup C: synE
N. meningitidis serogroup w135: synG
N. meningitidis serogroup X: xcbB
N. meningitidis serogroup Y: synF
[] Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Neisseria meningitidis serogroup Y synF gene
Part Type
Component (Describes the core component or analyte measured)
Created On
Construct for LOINC Short Name
N men sg Y synF

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Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gen synF del serogrupo Y de Neisseria meningitidis
zh-CN Chinese (China) 脑膜炎奈瑟菌血清群 Y synF 基因
it-IT Italian (Italy) Neisseria meningitidis sierogruppo Y, gene synF
Synonyms: Gene synF di Neisseria meningitidis sierogruppo Y
nl-NL Dutch (Netherlands) Neisseria meningitidis serogroep Y synF-gen
Synonyms: Neisseria meningitidis serogroep Y synF gen