LP248780-1
Thymidine synthase activity interpretation
Active
Description
Thymidine synthase is the enzyme that catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) using the methyl donor 5,10-methylenetetrahydrofolate (CH2THF) as a cofactor. dTMP is critical for DNA repair and replication. Thymidine synthase has become the target for drugs used in the treatment of some cancers including the drug 5-fluorouracil (5-FU). The active metabolite of 5-FU combines with the nucleotide binding site of TS which prevents dUMP from being able to bind with TS. The decreased amount of dUMP leads to decreased cell replication. Studies have shown that the gene amplification of TS in the tumor cells correlate to resistance to 5-FU. http://www.nature.com/nrc/journal/v3/n5/fig_tab/nrc1074_F2.html Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- Thymidine synthase activity interpretation
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2017-03-24
- Construct for LOINC Short Name
- TS act interp
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- CodeSystem lookup
- https:
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| it-IT | Italian (Italy) | Timidina, interpretazione dell'attività di sintesi Synonyms: Interpretazione dell''attività di sintesi della tim |
| es-ES | Spanish (Spain) | Actividad timidina sintetasa, interpretación |
| zh-CN | Chinese (China) | 胸苷合成酶活性解释 Synonyms: 胸苷（胸腺嘧啶脱氧核苷）合成酶（合酶）活性解释（说明） |
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