Version 2.78

Description

Dichlorodiphenyldichloroethane (o,p'- DDD or Mitotane) is an isomer of 4,4′-Dichlorodiphenyldichloroethane (p,p'DDD) used broadly as a pesticide. as well as an oral chemotherapeutic drug used to treat Cushing's syndrome and adrenal cortical carcinoma. o,p'- DDD directly suppresses the adrenal cortex and alters the degradation of steroids. Despite the ability of o,p'- DDD to prevent excess hormone production, its side-effects are difficult to tolerate. The adverse reactions include the following:
• gastrointestinal disorders: 80% of patients endured anorexia, nausea or vomiting, diarrhea
• central nervous system: 40% of patients experience depression in the form of lethargy and somnolence (25%) and dizziness and vertigo (15%)
• skin toxicity: 15% of patients transient rashes
• infrequently occurring adverse effects include: visual blurring, diplopia, lens opacity, toxic retinopathy, hematuria, hemorrhagic cystitis, albuminuria, hypertension, orthostatic hypotension, flushing, generalized aching, hyperpyrexia, lowered protein bound iodine
[http://flipper.diff.org/app/items/info/2929][CID: 6294] Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
o,p'- DDD
Part Type
Component (Describes the core component or analyte measured)
Created On
2017-08-23
Construct for LOINC Short Name
o,p'- DDD

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) o,p'- 二氯二苯二氯乙烷
Synonyms: o,p''-DDD;DDD;滴滴滴;米托坦;1-(2-氯苯基)-1-(4-氯苯基)-2,2-二氯乙烷
it-IT Italian (Italy) o,p'- Diclorodifenildicloroetano
Synonyms: o,p''- DDD
es-ES Spanish (Spain) o,p'- Diclorodifenildicloroetano