Version 2.77


The ALK (ALK receptor tyrosine kinase) gene [HGNC Gene ID:427] is located on chromosome 2 at 2p23.2-p23.1. This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily, and has been found to be rearranged, mutated, or amplified in a series of tumors including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumorigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] [NCBI Gene ID:238] Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Display Name
ALK gene
Part Type
Component (Describes the core component or analyte measured)
Created On
Construct for LOINC Short Name
ALK gene

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Language Variants Get Info

Tag Language Translation
it-IT Italian (Italy) ALK, gene
Synonyms: Gene ALK
es-ES Spanish (Spain) Gen ALK
zh-CN Chinese (China) ALK 基因
nl-NL Dutch (Netherlands) ALK-gen