Version 2.77

Description

The MET gene (MET proto-oncogene, receptor tyrosine kinase) [HGNC Gene ID:7029] is located on chromosome 7q31.2. This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016] [NCBI Gene ID:4233] Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Display Name
MET gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-01-05
Construct for LOINC Short Name
MET gene

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP265710-6

Language Variants Get Info

Tag Language Translation
it-IT Italian (Italy) MET, gene
Synonyms: Gene MET
es-ES Spanish (Spain) Gen MET
zh-CN Chinese (China) MET 基因
nl-NL Dutch (Netherlands) MET-gen