Version 2.80

Description

Zopiclone-N-oxide is one of two metabolites of eszopiclone and is not pharmacologically active.[http://www.who.int/medicines/areas/quality_safety/4.6ZopicloneCritReview.pdf] Eszopiclone is a cyclopyrrolones and a benzodiazepine receptor agonist derived from pyridine, pyrazine and piperazine and used to treat insomnia. Its mechanism of action is to bind to the omega-1 subtype of the alpha subunit of gamma-aminobutyrate-benzodiazepine GABA receptor complex (GABA-A). GABA-A is a chloride ionophore in the central nervous system, that when bound causes the chloride channels to open, leading to hyperpolarization, inhibition of neuronal firing, and an increase in the inhibition of GABA. This sequence of events causes an hypnotic response in the patient and induces sleep. Eszopiclone has insignificant anxiolytic activity and shows no evidence of causing increased liver enzymes in the blood.[CID 969472] Source: Regenstrief LOINC

Basic Part Properties

Part Name
Zopiclone-N-oxide
Part Display Name
Zopiclone-N-oxide
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-02-13
Construct for LOINC Short Name
Zopiclone-N-oxide

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP266154-6
ConceptMap translate
https://fhir.loinc.org/ConceptMap/$translate?system=http://loinc.org&code=LP266154-6

Language Variants Get Info

Tag Language Translation
it-IT Italian (Italy) Zopiclone-N-Ossido
zh-CN Chinese (China) N-氧化佐匹克隆
Synonyms: 佐匹克隆-N-氧化物;佐匹克隆N-氧化物;艾司佐匹克隆杂质A;右佐匹克隆相关物质A;氧化佐匹克隆;CAS 43200-96-0;EINECS 200-659-6
es-ES Spanish (Spain) Zopiclona-N-óxido
el-GR Greek (Greece) Ν-οξείδιο της ζοπικλόνης
Synonyms: Ν-οξείδιο της ζοπικλόνης