Version 2.78

Description

The p53 antigen was first discovered in 1979 and recognized as a tumor repressive gene in 1989. It encodes a protein that monitors the cell cycle by suppressing tumor growth and preventing genome mutation. When p53 is defective, abnormal cell proliferation can occur. Mutations in p53 are present in up to 50% of all human tumors. The three major functions of p53 include growth arrest, DNA repair, and apoptosis. P53 halts the growth arrest function of the cell cycle progress which can activate transcription of proteins that repair DNA. There are low levels of p53 in normal cells, but damage to DNA and similar stress signals may precipitate an increase of p53 protein. Cell death is the final course of action to prevent cells containing abnormal DNA from dividing. The concentration of P53 in cells is probably tightly controlled since high concentrations may accelerate aging due to excess apoptosis.[http://www.bioinformatics.org/p53/introduction.html] Ongoing studies are investigating the utility of the p53 antibody being used as a biomarker for the early detection of lung cancer in high risk asymptomatic patients. PMID: 21733826 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
p53 Ab
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-03-13
Construct for LOINC Short Name
p53 Ab

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP266571-1

Language Variants Get Info

Tag Language Translation
pl-PL Polish (Poland) p53 Ab
Synonyms: Przeciwciała do p53